Acute leukemia especially acute non-lymphoblastic leukemia when it is often given in association w/ thioguanine & an anthracycline eg, doxorubicin or daunorubicin. As regimen for Hodgkin’s disease, non-Hodgkin’s lymphomas, meningeal lymphoma & prophylaxis meningeal leukemia. Blast crisis of chronic myeloid leukemia, & treatment of lymphoma; management of myelodysplasia.